;

Pharmacy Product Info » Famous Brand Names »Singulair

Singulair

Singulair

 

 

Brand- Name

Singulair

Generic Name

Montelukast

Company

Merck & Co.

Disease/Medical Use

Asthma

First Approval Date

Feb-1998



Montelukastis a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to alleviate symptoms of seasonal allergies. It is usually administered orally. Montelukast is a CysLT1 antagonist that is it blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.

Because of its method of operation, it is not useful for the treatment of keen asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as theophylline.

Montelukast is an oral leukotriene receptor contender for the treatment of asthma and seasonal allergic rhinitis (hay fever). Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy). They are formed by cells, released, and then bound to other cells, and it is the binding to these other cells that stimulates the cells to promote inflammation. Montelukast works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes. Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs. Therefore, unlike zafirlukast, montelukast is not expected to affect the elimination of other drugs. The safety and effectiveness of montelukast has been demonstrated in children as young as 6 months of age. It was approved by the FDA in 1998.

 

 
Pharmacy Products |  History |  Drugs Generic Names |  Drugs Brand Names | Medical Information |  Link Exchange |  Links | Contact us |  Sitemap | Pharmacy Products News |  Pharmaceutical Companies |  Cancer Fighting Foods