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Positron emission tomography
Positron emission tomography (PET) is a nuclear medicine medical
imaging technique which produces a three dimensional image or map
of functional processes in the body.
A short-lived radioactive tracer isotope which decays
by emitting a positron, chemically combined with a metabolically
active molecule, is injected into the living subject (usually into
blood circulation). There is a waiting period while the metabolically
active molecule (usually a sugar) becomes concentrated in tissues
of interest, then the subject is placed in the imaging scanner.
The short-lived isotope decays, emitting a positron. After travelling
up to a few millimeters the positron annihilates with an electron,
producing a pair of gamma ray photons moving in opposite directions.
These are detected when they reach a scintillator material in the
scanning device, creating a burst of light which is detected by
photomultiplier tubes. The technique depends on simultaneous or
coincident detection of the pair of photons: photons which do not
arrive in pairs (i.e., within a few nanoseconds) are ignored. By
measuring where the gamma rays end up, their origin in the body
can be plotted, allowing the chemical uptake or activity of certain
parts of the body to be determined. The scanner uses the pair-detection
events to map the density of the isotope in the body, in the form
of slice images separated by about 5mm. The resulting map shows
the tissues in which the molecular probe has become concentrated,
and is read by a nuclear medicine physician or radiologist, to interpret
the result in terms of the patient's diagnosis and treatment. PET
scans are increasingly read alongside CT scans, the combination
giving both anatomic and metabolic information (what the structure
is, and what it is doing). PET is used heavily in clinical oncology
(medical imaging of tumours and the search for metastases) and in
human brain and heart research.
Alternative methods of scanning include computed tomography
(CT), magnetic resonance imaging (MRI) and functional magnetic resonance
imaging (fMRI) and single photon emission computed tomography (SPECT).
However, while other imaging scans such as CT and
MRI, isolate organic anatomic changes in the body, PET scanners
are capable of detecting areas of molecular biology detail (even
prior to anatomic change) via the use of radiolabelled molecular
probes that have different rates of uptake depending on the type
of tissue involved. The changing of regional blood flow in various
anatomic structures (as a measure of the injected positron emitter)
can be visualized and relatively quantified with a PET scan.
In order to properly interpret a PET scan result,
the resolution of the scanner must be known. Typically, determining
the resolution of a PET scanner is done with tiny wires that have
been irradiated in a nuclear reactor or a particle accelerator.
Another process involves using tiny beads of zeolite that have been
dipped into a saline solution containing technetium-99m. (Bailey,
et. al., 2004)
Radionuclides used in PET scanning are typically isotopes
with short half lives such as carbon-11, nitrogen-13, oxygen-15,
and fluorine-18 (half-lives of 20 min, 10 min, 2 min, and 110 min
respectively). Due to their short half lives, the isotopes must
be produced in a cyclotron at or near the site of the PET scanner.
Currently, 18-F is the only isotope approved by the FDA for distribution
in the US. Rubidium-82 is allowed limited use for myocardial perfusion
experiments. These isotopes are incorporated into compounds normally
used by the body such as glucose, water or ammonia and then injected
into the body to trace where they become distributed.
PET as a technique for scientific investigation is
limited by the need for clearance by ethics committees to inject
radioactive material into participants, and also by the fact that
it is not advisable to subject any one participant to too many scans.
Furthermore, due to the high costs of cyclotrons needed to produce
the short-lived radioisotopes for PET scanning (for example 18-F),
few hospitals and universities are capable of performing PET scans.
However, with the recent decision of Medicare to cover
PET scans for specific patients, there has been a recent
trend of increase in clinical use of PET scans throughout
the United States.
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